Hello Admin,

Here are some troubleshooting Tips for handling the profile Sync Issue. 

Problem Statements: Profile Setting is not saving at second login.

Technology used: Fslogix , Citrix UPM (multi Write back )and Citrix WEM

Way to troubleshoot.

1. Check the Fslogix Exclusions in redirection.xml for if any application folder is not synching

2. Check registry setting for HKLM\Polices\Citrix\user profile manager (ensure there is not inclusion or exclusions setting) only should have processed group setting and basic setting in user profile manager root.

3. reason could be if you used profile manager from WEM before deploying Fslogix and UPM for multi-Write back again so these old settings are not removed or overwritten after redeploying UPM.

4. once ensured all the above issues are fixed then try chnaging the setting and monitor.

it should work after making above listed changes.

Thanks

Admin